Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide–alkyne cycloaddition

• Maryna O. Mazur,
• Oleksii S. Zhelavskyi,
• Eugene M. Zviagin,
• Svitlana V. Shishkina,
• Vladimir I. Musatov,
• Maksim A. Kolosov,
• Elena H. Shvets,
• Anna Yu. Andryushchenko and
• Valentyn A. Chebanov

Beilstein J. Org. Chem. 2021, 17, 678–687, doi:10.3762/bjoc.17.57

• harder while the microwave-assisted catalyst-free conditions were effective for both terminal and non-terminal alkynes. Keywords: click chemistry; microwave chemistry; multicomponent reactions; triazolobenzodiazepines; Ugi reaction; Introduction Benzannulated heterocycles are among the most important

Camera-enabled techniques for organic synthesis

• Steven V. Ley,
• Richard J. Ingham,
• Matthew O’Brien and
• Duncan L. Browne

Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118

• Amberlyst 15 or Purolite CT-175 at temperatures between 100 and 150 °C. In another very nice example of the use of cameras to assist with organic synthesis, Leadbeater and co-workers report an application in microwave chemistry [47]. As all synthetic chemists are aware, laboratory microwave equipment

Antifreeze glycopeptide diastereomers

• Lilly Nagel,
• Carsten Budke,
• Axel Dreyer,
• Thomas Koop and
• Norbert Sewald

Beilstein J. Org. Chem. 2012, 8, 1657–1667, doi:10.3762/bjoc.8.190

• ; ice recrystallization; microwave chemistry; Introduction Several fish species living in polar and subpolar oceans have developed a strategy to survive in water at an average temperature of −1.8 °C. This non-colligative freezing-point depression is based on the prevention of ice growth in

Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monoliths

• Ping He,
• Stephen J. Haswell,
• Paul D. I. Fletcher,
• Stephen M. Kelly and
• Andrew Mansfield

Beilstein J. Org. Chem. 2011, 7, 1150–1157, doi:10.3762/bjoc.7.133

• where the reactants are present in the irradiation chamber for a short period of time [18][19]. Therefore, the application of microwave chemistry to scalable, continuous-flow processes, with commercially available microwave equipment and suitable flow instrumentation, is becoming increasingly important

Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor

• Bernhard Gutmann,
• Toma N. Glasnov,
• Tahseen Razzaq,
• Walter Goessler,
• Dominique M. Roberge and
• C. Oliver Kappe

Beilstein J. Org. Chem. 2011, 7, 503–517, doi:10.3762/bjoc.7.59

• Bernhard Gutmann Toma N. Glasnov Tahseen Razzaq Walter Goessler Dominique M. Roberge C. Oliver Kappe Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria Institute of Chemistry, Analytical

• ]. High-temperature processing offers many distinct advantages as demonstrated by the recent success of microwave-assisted organic synthesis [14][15][16][17][18]. In microwave chemistry, reaction times can often be reduced from hours to minutes by efficient and rapid direct dielectric heating of the

• reaction mixture in a sealed vessel to temperatures far above the boiling point of the solvent under atmospheric conditions. Since batch microwave chemistry is inherently difficult to scale up to production quantities [14][15][16], translating high-speed, high-temperature microwave chemistry to scalable